In dna, a purine must always pair with a pyrimidine and vice versa in order to ensure that10/17/2023 ![]() Under our conditions, the TFOs bind to their cognate double strand DNAs with binding constants of 2.6 × 10 5 and 2.3 × 10 6 M -1. We have analyzed triplex formation of two polypurine triplex forming oligodeoxynucleotides (TFOs) using fluorescence resonance energy transfer (FRET). ![]() ![]() Sequence specific triplex formation can be applied for gene targeting, gene silencing and mutagenesis. A third DNA strand can bind into the major groove of a homopurine duplex DNA to form a DNA triple helix.
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